Newcastle University
Research Technician
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Research Technician (Cancer Research) – £29,588.00 per annum
Closing Date: 29 July 2026
About the Role
The Newcastle Fibrosis Research Group is seeking a talented Research Technician to support a Cancer Research UK-funded project exploring the tumour immune microenvironment in hepatocellular carcinoma (HCC).
Based within the Faculty of Medical Sciences, this role will integrate with a multidisciplinary technical team under the oversight of a technical manager.
The research assesses how metabolic stress and hypoxia reprogram cancer-associated fibroblasts (CAFs), driving immune suppression and immunotherapy resistance in HCC—the world’s third leading cause of cancer-related death. Using advanced human and mouse pre-clinical models, alongside spatial and single-cell technologies, the project aims to:
- Define how CAFs influence the tumour microenvironment.
- Identify novel therapeutic strategies to enhance immunotherapy responses in liver cancer.
The technician will oversee key operational and scientific tasks, including:
- Maintenance of mouse colonies.
- Tissue processing, molecular/cellular biology techniques, and flow cytometry.
- Immunohistochemistry/immunofluorescence and support for spatial profiling studies.
- Laboratory administration—reagent preparation, compliance, stock management.
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This is a 100% FTE fixed-term position (3 years). Reduced-hours applications considered.
For inquiries, contact: Dr Jack Leslie (Jack.Leslie@newcastle.ac.uk)
Learn more about the Faculty of Medical Sciences
Key Responsibilities
- Managing day-to-day experimental work with human and mouse tissues/cells.
- Supporting (under supervision) and later performing HCC model experiments.
- Maintaining detailed, secure, up-to-date records of all lab activities.
- Liaising with suppliers and troubleshooting equipment issues/replacements.
- Assisting with safety documentation, compliance, and health/safety guidance.
- Prioritising task workflows to meet research deadlines.
- Contributing to project seminars and wider team presentations.
- Delegating (under direct supervision) lab space operations and policy compliance.
- Ensuring efficient resource management and cross-departmental coordination.
- Developing induction/training sessions for lab equipment/techniques.
- Assessing training needs for lab staff.
Note: Variable out-of-hours work may be required.
The Successful Candidate
Essential Knowledge & Experience
- Extensive health and safety awareness, including waste management.
- Technical laboratory experience (e.g., PCR, ELISAs, sterile cell culture, histology, immunohistochemistry).
- Strong teamwork, problem-solving, and organisational skills.
- Demonstrable ability to adapt to changing priorities.
- Proficiency in autonomous and collaborative work.
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Desirable Skills
- Flow cytometry experience.
Attributes & Cultural Fit
- Passion for cancer research/liver diseases.
- Eagerness to upskill in emerging methodologies.
- Excellent communication (written/oral) and interpersonal skills.
- Precision, adaptability, and commitment to collaborative solutions.
- Alignment with University/Faculty values.
Qualifications
- Essential: BTEC/HNC/HND (or equivalent) in biosciences or related fields.
- Desirable:
- BSc in biomedical/Clinical Sciences.
- Professional registration (e.g., accredited by a body like the HEA).
Newcastle University Commitments
Newcastle is a global, diverse, and inclusive institution committed to:
- Equality and opportunity (Gold Athena Swan, Bronze Race Equality Charter, Disability Confident).
- Support for sanctuary seekers.
- Welcoming applications from all backgrounds who enhance our university community’s depth and cohesion.
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