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Scientist
Scientist – Functional Genomics
Overview of the Role
Nucleome Therapeutics is unlocking the power of the human non-coding genome to drive breakthroughs in immune-mediated and complex diseases. We combine:
- High-resolution maps of 3D genome architecture
- Functional genomics
- Advanced sequencing technologies
- Computational innovation
to reveal novel regulatory mechanisms and therapeutic targets.
We are seeking a Scientist to join our growing Functional Genomics team, playing a key role in therapeutic target identification and validation. The ideal candidate will:
- Expand our suite of primary cell CRISPR workflows
- Develop bespoke genetic and phenotypic assays
- Collaborate closely with our drug discovery team to advance novel therapeutic programs
This role is perfect for a functional genomics scientist with experience applying CRISPR or other perturbation tools to complex primary cell systems.
Key Responsibilities
Genetic Target Investigation and Protocol Optimisation
- Design and execute experiments to investigate target gene function and mechanism in primary human cells, including:
- Designing experimental approaches and controls
- Optimising protocols to enhance data quality and reproducibility
- Troubleshooting technical challenges independently (with guidance from senior staff)
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Technological Innovation
- Contribute to the development and optimisation of CRISPR-based and other perturbation methods in primary cells.
Cross-Disciplinary Collaboration
- Collaborate closely with drug discovery to:
- Validate and prioritise therapeutic targets
- Expand the therapeutic development pipeline
- Partner with computational scientists to:
- Co-design experiments
- Define analysis requirements
- Ensure robust data generation
- Communicate findings clearly to scientific and non-scientific audiences via presentations and reports.
Data Interpretation and Decision Making
- Interpret and contextualise experimental results, contributing to conclusions and next-step recommendations.
Laboratory Practices and Continuous Improvement
- Maintain accurate, organised records of:
- Experimental design
- Data
- Outcomes
- Ensuring reproducibility and alignment with internal standards
- Contribute to lab improvements, including:
- Adopting new technologies
- Refining workflows
- Supporting best practices in experimental design and execution
- Adhere to best laboratory practices, including:
- Equipment maintenance
- Sample management
- Safety and quality standards
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Required Qualifications and Skills
Essential
- PhD in functional genomics or related discipline, or equivalent industry experience.
- Demonstrated experience in one or more of:
- CRISPR
- RNAi
- Other perturbation tool approaches
- Proven ability to work with primary cell types or complex cellular systems.
- Strong experimental design, data interpretation, troubleshooting, and problem-solving skills.
- Ability to develop and improve new skills to support projects.
- Capable of working independently and thriving in a multidisciplinary team.
- Strong communication skills to explain complex ideas to both specialists and non-specialists.
Desirable
- Background in applying functional genomics techniques to:
- Immune cells
- Investigating immune-related disorders
- Familiarity with the drug-discovery process or industry experience.
- Experience with advanced CRISPR tools, such as:
- Prime editing
- High-throughput screens
- Skill in NGS assays, including:
- RNA-seq
- ATAC-seq
- Single-cell outputs
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