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Scientist
Experimental DMPK Scientist – Oncology (12-Month Interim)
Location – DISC, Cambridge, UK Duration – 12 months (interim) IR35 Status – Inside
About the Role
We are seeking an Experimental DMPK Scientist to join the Oncology DMPK Experimental Team in AstraZeneca’s Discovery Centre, Cambridge, UK on a 12-month assignment. This role offers an exciting opportunity for a junior scientist with practical experience in bioanalysis and/or in vitro DMPK to support discovery-stage drug development within a collaborative scientific environment.
The successful candidate will play a key role in generating and interpreting high-quality experimental data to inform compound progression across oncology discovery projects.
Accountabilities
- Conduct laboratory-based studies to support discovery DMPK activities, with a focus on bioanalysis and/or in vitro DMPK.
- Execute established assays, including preparation, analysis, and documentation of experimental work.
- Partner closely with DMPK teams and multidisciplinary project groups to ensure timely delivery of high-quality data that supports project decision-making.
- Contribute to assay optimisation, troubleshooting, and continuous improvement of laboratory practices, while upholding science quality, data integrity, compliance, and safety standards.
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Essential Skills & Experience
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Degree in a relevant scientific discipline, such as:
- Chemistry
- Biochemistry
- Biology
- Pharmaceutical sciences
- Pharmacology
- Or equivalent.
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Practical laboratory experience in bioanalysis and/or in vitro DMPK.
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Understanding of fundamental DMPK principles and their application in drug discovery.
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Experience in handling and preparing biological samples for analysis.
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Ability to generate, review, and interpret experimental data accurately.
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Strong organisation skills—able to manage workload and meet agreed timelines.
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Excellent written and verbal communication skills.
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Capacity to work independently and collaboratively within a team.
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Commitment to safe working practices and high standards of data quality and integrity.
Desirable Skills & Experience
- Previous knowledge or interest in developing experience in core DMPK principles, including:
- Metabolic stability testing
- Microbial/microsomal or hepatocyte incubations
- Permeability studies
- Protein binding assays
- Experience with LC-MS/MS for quantitative bioanalysis.
- Familiarity with sample preparation techniques such as:
- Protein precipitation
- Liquid-liquid extraction
- Solid-phase extraction
- Understanding of how DMPK data influences compound optimisation in small-molecule drug discovery.
- Background in a pharmaceutical, biotech, or CRO environment (preferably oncology or medicinal chemistry focus).
- Awareness of assay performance, troubleshooting, and optimising laboratory workflows.
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Why Join AstraZeneca?
At AstraZeneca, we are driven by science and mission—committed to meaningful patient outcomes through cutting-edge drug discovery. This role offers:
✅ Selective oncology DMPK experience within a high-impact drug discovery team. ✅ Collaborative cross-disciplinary environment at Arizona’s state-of-the-art AstraZeneca Discovery Centre, Cambridge. ✅ Opportunity to develop expertise under expert guidance in a vibrant science community.
Join us in advancing new medicines that make a difference.
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