Almac Group
Senior Crystallisation Process Development Chemist
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Senior Crystallisation Process Development Chemist
Almac Sciences – Crystallisation Process Scientist
Location
Craigavon, Northern Ireland
Hours
37.5 hours per week, Monday–Friday. Flexible working arrangements available.
Business Unit
About Almac Sciences
Almac Sciences provides a comprehensive range of custom synthesis services, technology, and products to the pharmaceutical industry, supporting clients from drug discovery through to commercialisation. We specialise in accelerating entry into early-stage clinical development with robust, scalable solutions.
By joining Almac, you become part of a fast-paced, collaborative team within a highly regulated industry. Our mission is clear: we support our talent’s growth, build rewarding careers, and advance human health through innovative science. For more on our company culture, explore Life at Almac.
The Opportunity
The Crystallisation Process Scientist will:]
- Design, develop, and optimise crystallisation processes for Active Pharmaceutical Ingredients (APIs) and key intermediates.
- Apply solid-state chemistry, phase behaviour, and particle engineering principles to deliver scalable, GMP-compliant processes.
- Lead technical projects, mitigate risks associated with solid form control, crystallisation, and downstream processing.
- Ensure timely delivery to clients while meeting regulatory expectations.
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Key Responsibilities:
-
Process Development & Optimisation
- Design and execute crystallisation studies: solvent selection, supersaturation control, and seeding strategies.
- Develop procedures for solid form control (polymorphs, solvates, hydrates).
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Scientific Analysis
- Apply thermodynamic and kinetic principles to optimise nucleation, growth, and particle size distribution.
- Characterise solids and particles using techniques like XRPD, DSC, or microscopy.
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Process Robustness & Scale-up
- Define critical process parameters (CPPs) and critical material attributes (CMAs).
- Support scale-up and technology transfer to pilot/GMP plants.
- Troubleshoot challenges (oiling-out, filtration issues, polymorphic instability).
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Cross-functional Collaboration
- Work with synthetic chemistry, analytical, and engineering teams for integrated process understanding.
- Maintain compliant documentation (GMP and CMC compliance).
- Provide technical input for client reports and regulatory submissions.
Requirements
Essential:
- A degree in Chemistry, Chemical Engineering, or a closely related discipline.
- Proven experience in crystallisation process development and solid-state chemistry.
- Strong grasp of phase diagrams, solubility, and crystallisation kinetics.
- Industrial experience with scale-up and process robustness.
- Demonstrated ability to solve complex crystallisation challenges.
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Desirable:
- Postgraduate qualification (MSc/PhD) in Crystallisation, Solid-State Chemistry, or Particle Engineering.
- Experience with PAT tools (FBRM, PVM) and advanced crystallisation monitoring.
- Knowledge of polymorph screening and crystallisation risk strategies.
- Familiarity with GMP environments and regulatory expectations (CMC).
Why Join Almac?
- A supportive, collaborative culture in a high-growth organisation.
- Career progression opportunities and dedicated ** professional development**.
- Work in an industry critical to global health outcomes.
Notes for Recruitment Partners
Almac will only accept applications from agencies invited by our Talent Acquisition team. Unsolicited CVs will not be considered or processed.
Closing Date: Sunday 26 July 2026 at 5:00 PM
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