GSK
Senior Director Clinical Operations Asset Lead - Hepatology, renal and cardiovascular disease
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GSK Senior Clinical Operations Lead – Transforming Development through Strategic Delivery
Mission & Vision
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives.
We foster a culture of ambition for patients, accountability for impact, and commitment to doing the right thing, ensuring our efforts accelerate significant assets that meet patients’ needs with the highest probability of success. We unite science, technology, and talent to get ahead of disease together.
Position Summary
This is a senior leadership role at the forefront of clinical delivery, representing development operations at the asset level. As the Senior Clinical Operations Lead, you will hold strategic accountability for highly complex assets across multiple indications—including large Phase III global outcomes trials, rare disease programmes, and co-development partnerships—across critical therapeutic areas such as:
- Hepatology
- Renal disease
- Cardiovascular disease
Your role owns the asset-level operational strategy and delivery plans, ensuring alignment with scientific strategy while driving execution to time, cost, and quality.
Key Responsibilities
Strategic Clinical Operations Leadership
- Hold senior clinical operational accountability for a portfolio of complex assets (multi-indication/multi-disease) or a single, exceptional-scope programme (e.g., rare disease or co-development).
- Define and drive clinical operational delivery strategy at programme level, including:
- Country/site selection
- Diversity and health equity strategies
- Patient recruitment
- Implementation of innovative delivery approaches
- Own the portfolio-level risk register, lead scenario modelling and contingency planning, and escalate material risks to senior R&D leadership.
- Provide rigorous clinical operational input into:
- Clinical development plans
- Integrated evidence plans (including non-interventional and real-world evidence strategies)
- Represent GSK Clinical Operations in senior programme governance forums, serving as the primary operational escalation point.
- Lead CRO and vendor relationships at programme level, overseeing:
- Contract governance
- Performance management
- Strategic vendor reviews
Business Development & Rare Disease Expertise
- Deliver operational input to business development, including rare disease licensing and co-development partnerships.
- Lead clinical operations due diligence for in-licensing opportunities.
- Provide specialist leadership for rare disease programmes, such as:
- Small patient population recruitment models
- Accelerated regulatory pathways
- Patient advocacy group engagement
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Team & Quality Leadership
- Directly manage, coach, and develop a team of clinical operations leaders, setting the standard for delivery excellence.
- Drive portfolio-level inspection readiness and quality compliance, acting as the senior escalation point for quality issues.
Leading with Data & Enterprise Mindset
We seek a leader who goes beyond operational delivery—someone who uses data as a strategic asset and thinks at an enterprise level.
- Drive data-led decision making:
- Use portfolio analytics, delivery metrics, and external benchmarks to anticipate risks, prioritise investments, and communicate performance clearly.
- Champion data quality and integrity:
- Ensure operational data is accurate, timely, and decision-ready for both in-flight delivery and long-range planning.
- Apply enterprise-level thinking:
- Consider the impact of decisions on the wider organisation, not just your portfolio.
- Active contribution to function-wide strategy and capability building.
- Promote innovative trial methodologies:
- Digital patient-reported outcomes
- Decentralised/hybrid study elements
- Adaptive platform designs (where they add genuine patient value).
- Represent GSK externally as a subject matter expert, bringing competitive intelligence and industry insight back to the organisation.
Required Qualifications
Basic Requirements
To meet the ambition of our health goals, we seek professionals with:
- A degree in pharmacy, life sciences, medicine, or a related discipline.
- Significant senior clinical operations leadership experience in a pharmaceutical or CRO environment, with a track record delivering:
- Highly complex, multi-asset programmes across therapeutic areas:
- Hepatology
- Renal disease
- Cardiovascular disease
- Highly complex, multi-asset programmes across therapeutic areas:
- Experience in:
- Late-stage global trials (emphasis on large Phase III outcomes trials with morbidity/mortality endpoints across multi-national populations).
- Rare disease programmes, orphan drug pathways, or co-development models are highly desirable.
- Proven track record of direct line management and developing high-performing teams in a matrix environment.
- Strong analytical capability:
- Comfortable interrogating data to draw insights and translate them into strategic choices for senior audiences.
- Enterprise-level thinking:
- Balance operational detail with strategic perspective, aligning decisions with priorities beyond your immediate remit.
- Exceptional stakeholder influencing skills across:
- Scientific, commercial, regulatory, and external partner audiences.
- Experience managing:
- Outsourcing strategy
- CRO governance
- Budget management for large clinical programmes.
- Scientific literacy to engage credibly with medical, regulatory, and clinical science functions on complex late-phase programmes.
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Preferred But Not Mandatory
- An advanced qualification (postgraduate degree or equivalent).
- Location preference: Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA.
Compensation & Benefits (US Locations)
- Annual base salary range: $242,550–$404,250 (based on market, skills, experience, and education).
- Annual bonus and eligibility for:
- Share-based long-term incentive programme (linked to role level).
- Comprehensive benefits including:
- Healthcare and insurance (employee & family).
- Retirement contributions.
- Paid holidays, vacation, and caregiver/parental/medical leave.
Note: Salaries outside the US will be determined during recruitment.
Why GSK?
Our Culture & Purpose
By uniting science, technology, and talent, GSK gets ahead of disease together to impact health at scale.
Our therapeutic focus areas:
- Respiratory, immunology, and inflammation
- Oncology
- HIV
- Infectious diseases
A Workplace Where People Thrive
At GSK, we put patients and people first with a commitment to an environment where everyone can focus on their best work. Our pillars include:
- Ambitious for patients: Driving progress.
- Accountable for impact: Transparent, measurable outcomes.
- Doing the right thing: Ethical integrity in all decisions.
GSK is an Equal Opportunity Employer. We do not discriminate on the basis of race, colour, religion, sex (including pregnancy/gender identity/sexual orientation), parental status, national origin, age, disability, genetic information, military service, or other protected statuses.
Flexibility & Support
We’re proud to offer an agile working culture. Flexibility is key—explore opportunities with our hiring team to find what works best for you.
Additional Accommodations: If you require adjustments to our recruitment process (e.g., interview format), contact UKRecruitment.Adjustments@gsk.com. Alternatively, please see our Recruitment FAQ for more information.
Employment Businesses/Agencies: GSK does not accept referrals from agencies for these roles. All interested businesses must contact GSK’s procurement/human resources department in advance for written authorization.
For additional US Transparency policy details, please visit the CMS Open Payments Data.
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