Barrington James Drug Discovery & Preclinical
Senior Scientist
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Senior Cell Biologist — In Vivo & Translational
A growing biotechnology company is seeking an experienced Senior Cell Biologist to lead animal model and translational biology programmes across multiple oncology indications.
This is a high-impact opportunity for a scientist who can bridge in vitro cell biology with in vivo pharmacology, designing and overseeing preclinical studies that will generate critical efficacy, biodistribution, and translational data to support progression towards the clinic.
Key Responsibilities:
- Design, oversee and interpret in vivo efficacy and biodistribution studies across multiple oncology programmes
- Lead animal model studies, including coordination and management of outsourced CRO activities
- Develop and implement immunogenicity assessment strategies, including anti-Cas human PBMC ELISpot assays for pre-existing immunity and redosing scenarios
- Establish and manage patient-derived organoid (PDO) assay platforms to evaluate therapeutic selectivity
- Define pharmacodynamic strategies, including tumour molecular analysis and biomarker monitoring
- Perform hands-on cell biology experiments to support translational research programmes
- Collaborate cross-functionally to integrate preclinical data and inform development strategies
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Essential Requirements:
- PhD in Cancer Biology, Pharmacology, Immunology or a related scientific discipline
- 5+ years of hands-on experience in both in vivo models and in vitro cell biology
- Strong experience working with oncology models, including bladder, liver and/or lung cancer models
- Experience with local or intravesical delivery approaches in rodent models
- Expertise in biodistribution study design and tissue analysis techniques, including qPCR and IHC
- Hands-on experience with patient-derived organoid culture and functional assays
- Experience with immunology assays such as ELISpot
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Desirable Experience:
- Experience supporting GLP-adjacent or GLP-compliant preclinical studies
- Knowledge of animal study regulatory frameworks, including Australian or US requirements
- Previous experience working on gene therapy or gene editing programmes in vivo
This is an excellent opportunity for a translational scientist looking to take ownership of impactful preclinical programmes within a collaborative and innovative biotechnology environment.
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