AstraZeneca
Senior Scientist, Bioconjugation
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Senior Scientist, Bioconjugation
Senior Scientist, Bioconjugation
Location: Discovery Centre, Biomedical Campus, Cambridge, UK
Salary Package and Benefits – Competitive
About the Role
This is an exciting opportunity for a laboratory-based scientist to join the Oncology Targeted Discovery (OTD) Bioconjugation and Analytical team in Cambridge. You will play a pivotal role in Oncology drug discovery by delivering robust, high-quality data to support targeted drug projects.
As a Bioconjugation Scientist, you will collaborate across AstraZeneca to drive early-phase drug discovery while:
- Applying bioconjugation techniques to small molecules, antibodies, and related scaffolds.
- Designing, optimising, and scaling lab experiments independently.
- Ensuring high scientific rigour, data integrity, and compliance with Good Laboratory Practice (GLP), SHE standards, and all internal/external regulations.
This role requires a sticom background in Chemistry, Biochemistry, or Chemical Biology, with a passion for hands-on experimental work and analysis. A deep understanding of protein biochemistry and bioconjugation is essential, along with strong communication skills to interact with stakeholders and shape decision-making.
Responsibilities
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Experiment Design & Execution:
- Independently develop optimise, and scale up bioconjugation experiments for drug discovery.
- Apply metabolic analysis to evaluate conjugation outcomes.
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Data Generation & Communication:
- Interpret data with clear implications for drug discovery.
- Prepare, author, and review laboratory notebooks, protocols, and reports.
- Present technical findings to multidisciplinary audiences, ensuring clarity.
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Operational Excellence:
- Work independently or collaboratively across internal/external stakeholders.
- Stay updated on cutting-edge developments in therapeutics delivery.
- adhere to analytical and validation methodologies to ensure robust results.
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Compliance & Safety:
- Ensure all work (yours and peers) follows AstraZeneca's standards for lab safety (SHE standards), GLP, and industry regulations.
Skills & Experience
Essential Criteria
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PhD in Chemistry, Biochemistry, Bioengineering, or related fields. OR
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MSc/BSc in a relevant discipline with extensive industrial experience in bioconjugation, protein chemistry, or similar areas.
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Strong expertise in:
- Biochemical fundamentals, including synthetic chemistry, protein purification, stabilisation.
- Techniques for protein/bioconjugate characterisation (e.g., UV-Vis spectroscopy, HPLC/SEC-IEX-HIC, LC-MS).
- Purification workflows, including ÄKTA systems and tangential flow filtration (TFF).
- Successful execution of conjugation strategies and construct validation.
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Independent working with precision:
- Ability to plan, prioritise, and execute experiments with high integrity.
- Firm understanding of approaches to conjugated therapeutics delivery.
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Communication skills:
- Written & verbal clarity to convey technical data to all audience levels (specialists to decision-makers).
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Desirable (Plus Points)
- Direct experience with antibiody-drug conjugates (ADCs) or targeted therapies.
- Knowledge of protein stability assessment, aggregation studies, and biophysical characterisation (e.g., differential scanning calorimetry, analytical ultracentrifugation).
- Hands-on ability with high-throughput approaches or automated experimental workflows.
Why AstraZeneca?
Join a culture of inclusivity, collaboration, and growth—where you have the freedom to drive medicine towards the future.
- Unleash ideas: Fuel your entrepreneurial spirit in a Great Place to Work.
- Impact lives: Work on projects critical for patient and societal health.
- Work-life: A culture of lifelong learning, teamwork, and diversity.
Next Steps
Before applying, take time to envision yourself exceling in this role. Then check out our latest updates or apply today:
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This role closed on 16-July-2026 but explore similar opportunities or stay updated for future openings. Application support (e.g., reasonable accommodation/adjustments) is always available. AstraZeneca is committed to an inclusive hiring process.
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