Maxion Therapeutics
SENIOR SCIENTIST – TRANSLATIONAL BIOLOGY (12 month FTC)
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SENIOR SCIENTIST – TRANSLATIONAL BIOLOGY (12 month FTC)
SENIOR SCIENTIST – TRANSLATIONAL BIOLOGY
(12 month FTC Maternity Cover)
About Maxion
Maxion designs new class of biologics by harnessing knottins, one of nature’s most potent modulators of ion channels and G protein-coupled receptors (GPCRs). By combining knottins with an antibody’s drug properties, we develop transformative treatments achieving higher specificity and durability for patients with ion channel and GPCR-driven diseases. Initially focused on immunological diseases, heart disorders, and chronic pain, our KnotBody® pipeline targets previously unreachable biological mechanisms.
Founded in 2020 by distinguished biotech leaders Dr John McCafferty (CTO) and Dr Aneesh Karatt-Vellatt (CSO), Maxion leverages groundbreaking expertise from Protein phage display (pioneered by McCafferty and his Nobel-winning collaborator Dr Gregory Winter). Headquartered near Cambridge, UK, the company is backed by global blue-chip investors.
Visit Maxion for more details.
About the Role
We are seeking a highly informed and proactive Senior Scientist specialising in human immunology to join our Translational Biology team on a fixed-term basis. Reporting to the Director of Translational Biology, this role focuses on developing disease-specific in vitro/ex vivo models, delivering mechanism-of-action (MOA) data, and guiding indication selection. The successful candidate will contribute directly to our discovery pipeline and thrive in our dynamic, agile work environment.
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Key Responsibilities
- Develop and refine in vitro and ex vivo models using primary human immune cells/tissue relevant to target diseases.
- Characterise the pharmacological profiles and MOA of KnotBodies in primary immunology models.
- Support translational teams in designing and interpreting in vivo experiments.
- Analyse, interpret, and communicate data clearly—both verbally and in writing—to internal stakeholders.
- Troubleshoot daily challenges with problem-solving efficiency.
- Maintain accurate laboratory records, including timely and precise notebook documentation.
Candidate Profile
Essential Qualifications
- PhD in Immunology, Pharmacology, or a related field.
- Relevant postdoctoral or industrial experience (critical for eligibility).
- Proven expertise in:
- Primary human PBMCs and tissue use.
- Biologic characterisation assays, including:
- Cell binding analyses.
- Immunomodulatory assays for activation and proliferation.
- Flow cytometry (multiparameter) and cell sorting techniques.
- Flow cytometry (technique proficiency, including gating and complex data analysis).
- ELISA/MSD for target engagement.
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Desired Attributes
- Thrives in innovative, fast-paced and collaborative environments.
- Adapts quickly to evolving scientific challenges.
- Possesses a can-do attitude and resilience under pressure.
- Actively shares progressive ideas to enhance team productivity.
What We Offer
- Competitive salary aligned to expertise and experience.
- Generous employer pension contributions, private life insurance, and medical insurance.
- Cycle To Work Scheme.
- Modern Science Park lab nested near Cambridge (accessible by car, train or bus), with on-site amenities—gym, café, and vibrant social community.
- Collaboration with a team of visionary scientists, including co-founders who are Key Opinion Leaders in their fields.
- Supportive team culture that values openness and collaborative scientific exchange.
How to Apply
Submit your application via our [direct link]( Herbert link – replaced by placeholder) including:
- Curriculum Vitae with current role details.
- Cover letter outlining:
- How your background makes you a strong fit.
- Your experience and remuneration expectations.
Note: Agency discretionary not required.
This is a 12-month fixed-term position. No viable supply-side engagement sought.
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