Senior Technical Program Manager - Preclinical, London

What you will do Drive non-clinical IND needs: You will manage the timeline and sequencing of late-stage discovery including CMC, DMPK, pharmacology and tox reporting to enable successful submission, ensuring no critical path items are missed. You will partner closely with counterparts in our clinical team to ensure non-clinical and clinical aspects of the IND are integrated correctly. Program Management: Create and maintain rigorous project plans that monitor sequencing in a highly detailed way. You will track dependencies across multiple workstreams to ensure alignment with submission goals, including working with a network of external vendors and collaborators and managing large budgets. Data Management: Play a leading role in the transition of document and data management workflows from general cloud storage (e.g., Google Drive) to submission-ready systems. You will ensure our data integrity and documentation meet the regulatory standards required for development. Cross-Functional Coordination: Act as the operational hub for interdisciplinary teams, facilitating seamless communication between scientific teams, technical operations, and regulatory consultants to keep programs on track. Risk Mitigation: Proactively identify and document risks in the pre-clinical phase and devise mitigation strategies in partnership with Program Leads before they impact timelines. Operational Excellence: Partner with the DDMR Leads to refine the operating model for pre-clinical development, helping to establish the world class infrastructure required for future programs.

Skills and qualifications Essential: You must have a proven track record of managing an IND application process from late discovery/pre-clinical all the way through to submission. Deep experience working at the intersection of discovery and early development; you understand the specific scientific and operational shifts that occur during this transition. Experience implementing or managing regulatory-compliant document management systems. Experience working with external vendors and collaborators. Experience managing large budgets. You have the ability to be "in the weeds" managing complex schedules and logistics, while possessing enough industry experience to provide high-level strategic input on regulatory hurdles. Exceptional organisational skills with a mastery of sequencing complex, multi-disciplinary activities. Nice to have: Scientific MSc or PhD in Biology, Chemistry/protein engineering, toxicology or a related discipline. Formal program management qualification (e.g., PMP, PRINCE2) Experience in a high-growth Biotech or TechBio environment Experience working on multiple modalities (small molecules, biologics, …)

Culture and values We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.

Creating an extraordinary company We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our privacy policy.

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