Charles River Laboratories
Senior Technical Specialist - DMPK
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For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.
Job Overview
Are you already an experienced bioanalyst looking for your next role?
Do you have refined skills in LC-MS maintenance and troubleshooting?
Are you proficient in bespoke method development within small molecules?
If you answered yes to any, or all of those questions then good news, our Cambridge site have a vacancy for a Senior Technical Specialist - DMPK! Apply today!
A highly experienced lab and office based bioanalyst providing wide in-depth scientific and technical expertise to both multidisciplinary integrated Drug Discovery projects and standalone DMPK projects.
This role combines hands-on bioanalytical expertise with project leadership, mentoring, and continuous improvement responsibilities to support small and large molecule drug discovery programmes.
Offering you opportunities across varied DMPK and broader scientific projects and development across multiple scientific and technical areas.
Main Tasks
- Developing, optimising and executing the bioanalysis of samples from in vivo DMPK studies for small and large molecule drug discovery projects in an early discovery setting.
- Extensive knowledge of modern UPLC-MS systems and software including chromatographic method development.
- Demonstrated ability to perform routine and complex troubleshooting, maintenance, and optimisation of mass spectrometry and LC equipment, ensuring reliable operation and rapid resolution of technical issues.
- Experience in the analysis of different sample types such as plasma, blood, brain, lung, bile, faeces, urine.
- Demonstrated experience of pharmacokinetic parameter determination and an understanding of the underlying principles.
- Comprehensive troubleshooting and problem-solving skills using both technical and scientific expertise.
- Strong organisation and time management skills alongside an inbuilt flexibility to adapt to change.
- Excellent communication skills and be an effective team player; these will be essential to successful execution of projects whilst working in a matrix and multi-skilled environment.
- Lead scientific and technical projects, ensuring delivery of high-quality data to agreed timelines.
- Drive innovation through the development of novel assays, protocols and analytical approaches.
- Mentor, coach and develop colleagues, acting as a technical role model and recognised subject matter expert.
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Qualifications And Experience
- BSc or equivalent in relevant scientific area.
- Industry experience in pharma, biotech or other commercial organisations.
- Expert user of Mass Spectrometry instrumentation.
- Experience in the bioanalytical method development of challenging analytes, in complex matrices.
- Accurate & diligent experimental planning, execution and troubleshooting.
- Good communication skills (verbal/written) internally and externally.
- Excellent team player.
- Positive ‘can do’ attitude. Creative problem solving.
- Ability to plan & execute work independently.
- Project management.
- Strong organisation and time management skills alongside an inbuilt flexibility to adapt to change.
- Experience of guiding/mentoring junior colleagues.
- LC-MS/MS maintenance and troubleshooting.
- Bespoke method development for small molecules.
What We Offer You
Charles River Laboratories provides a competitive benefits package starting from day one of employment.
Financial & Retirement
- Highly competitive pension contribution packages
- Group life assurance
- Bonus and group income protection
Health & Wellness
- Private medical insurance (often extending to family members)
- Private dental care
- 24/7 remote GP access
- Critical illness cover
Work-Life Balance
- Generous parental leave policies
- Flexible working arrangements depending on business needs
- The option to buy or sell annual leave
Additional Perks
- Cycle to work scheme
- Electric car scheme
- Paid professional development and training opportunities
- A dedicated employee assistance programme for well-being support
About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.
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About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.
At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.
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